Negative vaccine efficacy
Behavioral and Health Outcomes of mRNA COVID-19 Vaccination: A Case-Control Study in Japanese Small and Medium-Sized Enterprises
Published: December 13, 2024
to urgently evaluate the effects,
? COVID-19 infection rates
? related behaviors changes
Results
N = 913 participants
Adjusted ORs for COVID-19 infection among vaccinated individuals, compared to unvaccinated individuals
1.85 (p less than 0.001)
A higher percentage of participants who contracted COVID-19 had received at least one dose of the vaccine
Odds of contracting COVID-19 increased with the number of vaccine doses:
One to two doses, OR: 1.63, (p = 0.020)
Three to four doses, OR: 2.04, (p = 0.001)
Five to seven doses, OR: 2.21, (p = 0.033).
Behavioral analysis indicated that a reduced frequency of bathing and exercising,
was significantly associated with higher COVID-19 infection rates
i.e. bathing frequency and exercising were preventative for infection
Negative efficacy
Conclusions
The study observed a higher reported incidence of COVID-19 infection among vaccinated individuals during the pandemic period
Infections positivily corelated with number of vaccine does
This paradoxical finding may be influenced by various factors,
including immune response mechanisms,
increasing T suppressor (regulatory cells)
antibody-dependent enhancement (ADE),
original antigenic sin,
behavioral changes,
exposure risk.
Understanding these factors is crucial for urgently enhancing public health strategies and vaccination programs.
Methods
A case-control study
Data collected from Japan Small and Medium Enterprise Management Council, December 2023.
Survey gathered information on
demographic characteristics,
COVID-19 infection status,
vaccination history,
health status before January 2020,
various preventive behaviors.
Primary outcome, presence or absence of COVID-19 infection.
Association between vaccination status and COVID-19 infection.
Cleveland Clinic
https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v3
Health-care workers 1,359 unvaccinated,
who had previously tested positive,
non got infected
The study authors concluded:
“individuals who have had SARS-CoV-2 infection are unlikely to benefit from covid-19 vaccination.”