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Negative vaccine efficacy

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Behavioral and Health Outcomes of mRNA COVID-19 Vaccination: A Case-Control Study in Japanese Small and Medium-Sized Enterprises

Published: December 13, 2024

https://www.cureus.com/articles/313843-behavioral-and-health-outcomes-of-mrna-covid-19-vaccination-a-case-control-study-in-japanese-small-and-medium-sized-enterprises?utm_source=substack&utm_medium=email#!/ />
Understanding the impact of messenger RNA (mRNA) COVID-19 vaccination,

to urgently evaluate the effects,

? COVID-19 infection rates

? related behaviors changes

Results

N = 913 participants

Adjusted ORs for COVID-19 infection among vaccinated individuals, compared to unvaccinated individuals

1.85 (p less than 0.001)

A higher percentage of participants who contracted COVID-19 had received at least one dose of the vaccine

Odds of contracting COVID-19 increased with the number of vaccine doses:

One to two doses, OR: 1.63, (p = 0.020)

Three to four doses, OR: 2.04, (p = 0.001)

Five to seven doses, OR: 2.21, (p = 0.033).

Behavioral analysis indicated that a reduced frequency of bathing and exercising,

was significantly associated with higher COVID-19 infection rates

i.e. bathing frequency and exercising were preventative for infection

Negative efficacy

Conclusions

The study observed a higher reported incidence of COVID-19 infection among vaccinated individuals during the pandemic period

Infections positivily corelated with number of vaccine does

This paradoxical finding may be influenced by various factors,

including immune response mechanisms,

increasing T suppressor (regulatory cells)

antibody-dependent enhancement (ADE),

original antigenic sin,

behavioral changes,

exposure risk.

Understanding these factors is crucial for urgently enhancing public health strategies and vaccination programs.

Methods

A case-control study

Data collected from Japan Small and Medium Enterprise Management Council, December 2023.

Survey gathered information on

demographic characteristics,

COVID-19 infection status,

vaccination history,

health status before January 2020,

various preventive behaviors.

Primary outcome, presence or absence of COVID-19 infection.

Association between vaccination status and COVID-19 infection.

Cleveland Clinic

https://www.medrxiv.org/content/10.1101/2021.06.01.21258176v3

Health-care workers 1,359 unvaccinated,

who had previously tested positive,

non got infected

The study authors concluded:

“individuals who have had SARS-CoV-2 infection are unlikely to benefit from covid-19 vaccination.”

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